Clinically used drug, Niclosamide, could make the difference in Parkinson's disease

Researchers at Cardiff University, in collaboration with the University of Dundee, have identified a drug molecule within a medicine used to treat tapeworm infections which could lead to new treatments for patients with Parkinson's disease.

Over the last decade or so, researchers striving to find a cure for this debilitating disease have focused their attention on a protein found in the human body known as PINK1. It's understood that the malfunction of this protein is one of the leading causes of Parkinson's disease.

Several studies have suggested that discovering a drug which is capable of enhancing the function of PINK1 could be a significant step in halting neurodegeneration and therefore slow down or even treat Parkinson's disease.

With this knowledge in mind, researchers at Cardiff and Dundee Universities have discovered that a drug traditionally used to treat tapeworm infections, named Niclosamide, is also an effective activator of the PINK1 protein.

Furthermore, the research, funded by The Welcome Trust, revealed that Niclosamide and some of its derivatives could enhance PINK1 performance within cells and neurons. This has given the researchers reason to believe that this drug could provide new hope for patients living with Parkinson's disease. This is the first report of a clinically used drug that could be used to activate PINK1 and may hold promise in treating Parkinson's disease. 

 

Sources:

Text: https://www.news-medical.net/news/20171212/Tapeworm-drug-could-provide-new-hope-for-patients-with-Parkinsons-disease.aspx

Photo: https://www.tsa.gov/blog/2013/09/24/tsa-travel-tips-tuesday-traveling-medication